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Assay Detail

CHEMBL661762

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Binding
Binding affinity was measured on Cytochrome P450 19A1
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Mechanism and inhibition of cytochrome P-450 aromatase.
Cole PA, Robinson CH.
J Med Chem (1990) 33 : 2933 -2942
PubMed 2231592 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 30 7.17 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98998 1 9.00
CHEMBL281433 1 9.00
CHEMBL101540 1 9.00
CHEMBL98537 2 8.89
CHEMBL9298 FADROZOLE 2.0 1 8.82
CHEMBL421018 1 8.64
CHEMBL98685 1 8.52
CHEMBL98105 1 8.33
CHEMBL329500 1 8.30
CHEMBL26093 1 8.15
CHEMBL319108 1 8.05
CHEMBL319961 1 7.92
CHEMBL283196 ALPHA-NAPHTHOFLAVONE 1 7.70
CHEMBL1629804 1 7.43
CHEMBL101323 1 7.43
CHEMBL132530 FORMESTANE 2.0 1 7.30
CHEMBL99706 1 7.25
CHEMBL282580 1 7.12
CHEMBL28806 1 7.12
CHEMBL2311178 1 6.75
CHEMBL1078534 ANDROSTENEDONE 1 6.50
CHEMBL3085491 1 6.41
CHEMBL488 AMINOGLUTETHIMIDE 4.0 1 6.22
CHEMBL101947 1 5.96
CHEMBL101595 1 5.52
CHEMBL101893 1 4.60
CHEMBL100615 1 4.48
CHEMBL99370 1 4.46
CHEMBL157101 KETOCONAZOLE 4.0 1 4.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98998 Ki = 1.0 nM 9.00
CHEMBL281433 Ki = 1.0 nM 9.00
CHEMBL101540 Ki = 1.0 nM 9.00
CHEMBL98537 Ki = 1.3 nM 8.89
CHEMBL9298 FADROZOLE Ki = 1.5 nM 8.82
CHEMBL421018 Ki = 2.3 nM 8.64
CHEMBL98685 Ki = 3.0 nM 8.52
CHEMBL98105 Ki = 4.7 nM 8.33
CHEMBL329500 Ki = 5.0 nM 8.30
CHEMBL26093 Ki = 7.0 nM 8.15
CHEMBL319108 Ki = 9.0 nM 8.05
CHEMBL319961 Ki = 12.0 nM 7.92
CHEMBL283196 ALPHA-NAPHTHOFLAVONE Ki = 20.0 nM 7.70
CHEMBL101323 Ki = 37.0 nM 7.43
CHEMBL1629804 Ki = 37.0 nM 7.43
CHEMBL132530 FORMESTANE Ki = 50.0 nM 7.30
CHEMBL99706 Ki = 56.0 nM 7.25
CHEMBL282580 Ki = 75.0 nM 7.12
CHEMBL28806 Ki = 75.0 nM 7.12
CHEMBL2311178 Ki = 180.0 nM 6.75
CHEMBL1078534 ANDROSTENEDONE Ki = 320.0 nM 6.50
CHEMBL3085491 Ki = 390.0 nM 6.41
CHEMBL488 AMINOGLUTETHIMIDE Ki = 600.0 nM 6.22
CHEMBL98537 Ki = 890.0 nM 6.05
CHEMBL101947 Ki = 1100.0 nM 5.96
CHEMBL101595 Ki = 3000.0 nM 5.52
CHEMBL101893 Ki = 25000.0 nM 4.60
CHEMBL100615 Ki = 33000.0 nM 4.48
CHEMBL99370 Ki = 35000.0 nM 4.46
CHEMBL157101 KETOCONAZOLE Ki = 65000.0 nM 4.19