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Assay Detail

CHEMBL661791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type A receptor of guinea pig pancreas
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL3501)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Minor structural differences in Boc-CCK-4 derivatives dictate affinity and selectivity for CCK-A and CCK-B receptors.
Shiosaki K, Lin CW, Kopecka H, Bianchi B, Miller T, Stashko M, Witte D.
J Med Chem (1997) 40 : 1169 -1172
PubMed 9089338 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.70 8.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL320868 1 8.42
CHEMBL3142912 1 8.24
CHEMBL3142923 1 8.03
CHEMBL3142924 1 7.85
CHEMBL3142905 1 7.82
CHEMBL98468 1 7.80
CHEMBL3142899 1 7.72
CHEMBL3142903 1 7.66
CHEMBL100609 1 7.64
CHEMBL3142906 1 7.47
CHEMBL3143025 1 7.39
CHEMBL3142898 1 7.34
CHEMBL262767 1 7.28
CHEMBL3142904 1 7.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL320868 IC50 = 3.8 nM 8.42
CHEMBL3142912 IC50 = 5.8 nM 8.24
CHEMBL3142923 IC50 = 9.4 nM 8.03
CHEMBL3142924 IC50 = 14.0 nM 7.85
CHEMBL3142905 IC50 = 15.0 nM 7.82
CHEMBL98468 IC50 = 16.0 nM 7.80
CHEMBL3142899 IC50 = 19.0 nM 7.72
CHEMBL3142903 IC50 = 22.0 nM 7.66
CHEMBL100609 IC50 = 23.0 nM 7.64
CHEMBL3142906 IC50 = 34.0 nM 7.47
CHEMBL3143025 IC50 = 41.0 nM 7.39
CHEMBL3142898 IC50 = 46.0 nM 7.34
CHEMBL262767 IC50 = 53.0 nM 7.28
CHEMBL3142904 IC50 = 71.0 nM 7.15