Assay Detail
Binding
CHEMBL661822
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Evaluated in vitro for its binding affinity towards cholecystokinin type A receptor of guinea pig pancreas
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | guinea pig |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.55 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269016 | — | — | 1 | 9.30 |
| CHEMBL263742 | — | — | 1 | 9.00 |
| CHEMBL269355 | — | — | 1 | 8.38 |
| CHEMBL99499 | — | — | 1 | 8.28 |
| CHEMBL2310857 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269016 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL263742 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL269355 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL99499 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2310857 | — | IC50 | = | 16.0 | nM | 7.80 |