Assay Detail
Binding
CHEMBL661827
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Binding affinity towards cholecystokinin type A receptor in guinea pig pancreas by using [125I]BH-CCK-8 as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Pancreas |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-a receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.63 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142691 | — | — | 1 | 8.35 |
| CHEMBL3142690 | — | — | 1 | 8.07 |
| CHEMBL98468 | — | — | 1 | 7.80 |
| CHEMBL3142899 | — | — | 1 | 7.72 |
| CHEMBL319814 | — | — | 1 | 7.58 |
| CHEMBL3142905 | — | — | 1 | 7.58 |
| CHEMBL262767 | — | — | 1 | 7.28 |
| CHEMBL3142698 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142691 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3142690 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL98468 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3142899 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL319814 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3142905 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL262767 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3142698 | — | IC50 | = | 220.0 | nM | 6.66 |