Assay Detail
Binding
CHEMBL661837
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Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 1,5-benzodiazepindione gastrin/CCKB antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.68 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320624 | — | — | 1 | 9.40 |
| CHEMBL95200 | — | — | 1 | 8.80 |
| CHEMBL320141 | — | — | 1 | 8.60 |
| CHEMBL421575 | — | — | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320624 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL95200 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL320141 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL421575 | — | Ki | = | 12.59 | nM | 7.90 |