Assay Detail
Binding
CHEMBL661844
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Inhibitory activity against chicken liver dihydrofolate reductase
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 71 | 4.62 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31547 | — | — | 1 | 5.67 |
| CHEMBL274031 | — | — | 1 | 5.63 |
| CHEMBL56101 | — | — | 1 | 5.26 |
| CHEMBL57582 | — | — | 1 | 5.25 |
| CHEMBL31946 | — | — | 1 | 5.22 |
| CHEMBL281760 | — | — | 1 | 5.17 |
| CHEMBL31235 | — | — | 1 | 5.08 |
| CHEMBL18898 | — | — | 1 | 5.03 |
| CHEMBL417095 | — | — | 1 | 5.01 |
| CHEMBL277391 | — | — | 1 | 4.99 |
| CHEMBL19790 | — | — | 1 | 4.92 |
| CHEMBL31351 | — | — | 1 | 4.83 |
| CHEMBL56146 | — | — | 1 | 4.83 |
| CHEMBL280884 | — | — | 1 | 4.83 |
| CHEMBL285209 | — | — | 1 | 4.79 |
| CHEMBL19293 | — | — | 1 | 4.79 |
| CHEMBL19780 | — | — | 1 | 4.79 |
| CHEMBL29712 | — | — | 1 | 4.79 |
| CHEMBL56282 | — | — | 1 | 4.77 |
| CHEMBL291931 | — | — | 1 | 4.74 |
| CHEMBL21395 | — | — | 1 | 4.74 |
| CHEMBL30937 | — | — | 1 | 4.73 |
| CHEMBL19406 | — | — | 1 | 4.72 |
| CHEMBL22146 | — | — | 1 | 4.72 |
| CHEMBL57160 | — | — | 1 | 4.71 |
| CHEMBL31912 | — | — | 1 | 4.71 |
| CHEMBL265493 | — | — | 1 | 4.71 |
| CHEMBL19772 | — | — | 1 | 4.70 |
| CHEMBL56129 | — | — | 1 | 4.68 |
| CHEMBL32793 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31547 | — | Ki | = | 2137.96 | nM | 5.67 |
| CHEMBL274031 | — | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL56101 | — | Ki | = | 5495.41 | nM | 5.26 |
| CHEMBL57582 | — | Ki | = | 5623.41 | nM | 5.25 |
| CHEMBL31946 | — | Ki | = | 6025.6 | nM | 5.22 |
| CHEMBL281760 | — | Ki | = | 6760.83 | nM | 5.17 |
| CHEMBL31235 | — | Ki | = | 8317.64 | nM | 5.08 |
| CHEMBL18898 | — | Ki | = | 9332.54 | nM | 5.03 |
| CHEMBL417095 | — | Ki | = | 9772.37 | nM | 5.01 |
| CHEMBL277391 | — | Ki | = | 10232.93 | nM | 4.99 |
| CHEMBL19790 | — | Ki | = | 12022.64 | nM | 4.92 |
| CHEMBL31351 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL56146 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL280884 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL29712 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL19293 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL19780 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL285209 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL56282 | — | Ki | = | 16982.44 | nM | 4.77 |
| CHEMBL291931 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL21395 | — | Ki | = | 18197.01 | nM | 4.74 |
| CHEMBL30937 | — | Ki | = | 18620.87 | nM | 4.73 |
| CHEMBL19406 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL22146 | — | Ki | = | 19054.61 | nM | 4.72 |
| CHEMBL265493 | — | Ki | = | 19498.45 | nM | 4.71 |
| CHEMBL31912 | — | Ki | = | 19498.45 | nM | 4.71 |
| CHEMBL57160 | — | Ki | = | 19498.45 | nM | 4.71 |
| CHEMBL19772 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL56129 | — | Ki | = | 20892.96 | nM | 4.68 |
| CHEMBL32793 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL56602 | — | Ki | = | 24547.09 | nM | 4.61 |
| CHEMBL57383 | — | Ki | = | 25703.96 | nM | 4.59 |
| CHEMBL416177 | — | Ki | = | 27542.29 | nM | 4.56 |
| CHEMBL31891 | BRODIMOPRIM | Ki | = | 28840.32 | nM | 4.54 |
| CHEMBL300114 | — | Ki | = | 29512.09 | nM | 4.53 |
| CHEMBL19633 | DIAVERIDINE | Ki | = | 34673.69 | nM | 4.46 |
| CHEMBL18967 | — | Ki | = | 35481.34 | nM | 4.45 |
| CHEMBL19414 | — | Ki | = | 42657.95 | nM | 4.37 |
| CHEMBL31462 | — | Ki | = | 42657.95 | nM | 4.37 |
| CHEMBL57034 | — | Ki | = | 43651.58 | nM | 4.36 |
| CHEMBL18912 | — | Ki | = | 45708.82 | nM | 4.34 |
| CHEMBL280378 | EPIROPRIM | Ki | = | 46773.51 | nM | 4.33 |
| CHEMBL434787 | — | Ki | = | 46773.51 | nM | 4.33 |
| CHEMBL19771 | — | Ki | = | 47863.01 | nM | 4.32 |
| CHEMBL59369 | — | Ki | = | 48977.88 | nM | 4.31 |
| CHEMBL32067 | — | Ki | = | 48977.88 | nM | 4.31 |
| CHEMBL298955 | — | Ki | = | 48977.88 | nM | 4.31 |
| CHEMBL56318 | METIOPRIM | Ki | = | 51286.14 | nM | 4.29 |
| CHEMBL19023 | — | Ki | = | 51286.14 | nM | 4.29 |
| CHEMBL31055 | — | Ki | = | 53703.18 | nM | 4.27 |