Assay Detail
Binding
CHEMBL661845
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Inhibitory activity against isolated chicken liver dihydrofolate reductase (DHFR)
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 6.89 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33066 | — | — | 1 | 7.72 |
| CHEMBL286571 | — | — | 1 | 7.70 |
| CHEMBL33633 | — | — | 1 | 7.58 |
| CHEMBL21077 | — | — | 1 | 7.55 |
| CHEMBL33697 | — | — | 1 | 7.55 |
| CHEMBL433045 | — | — | 1 | 7.50 |
| CHEMBL20227 | — | — | 1 | 7.47 |
| CHEMBL20528 | — | — | 1 | 7.46 |
| CHEMBL33179 | — | — | 1 | 7.40 |
| CHEMBL30475 | — | — | 1 | 7.37 |
| CHEMBL7130 | — | — | 1 | 7.36 |
| CHEMBL33010 | — | — | 1 | 7.35 |
| CHEMBL268088 | — | — | 1 | 7.35 |
| CHEMBL30594 | — | — | 1 | 7.33 |
| CHEMBL418741 | — | — | 1 | 7.29 |
| CHEMBL33750 | — | — | 1 | 7.22 |
| CHEMBL6771 | — | — | 1 | 7.20 |
| CHEMBL417461 | — | — | 1 | 7.18 |
| CHEMBL20466 | — | — | 1 | 7.15 |
| CHEMBL266025 | — | — | 1 | 7.15 |
| CHEMBL20480 | — | — | 1 | 7.14 |
| CHEMBL441503 | — | — | 1 | 7.10 |
| CHEMBL284133 | — | — | 1 | 7.03 |
| CHEMBL286618 | — | — | 1 | 7.02 |
| CHEMBL34043 | — | — | 1 | 7.01 |
| CHEMBL280726 | — | — | 1 | 6.56 |
| CHEMBL34217 | — | — | 1 | 6.50 |
| CHEMBL30884 | — | — | 1 | 6.48 |
| CHEMBL33739 | — | — | 1 | 6.46 |
| CHEMBL266319 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33066 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL286571 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL33633 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL21077 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL33697 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL433045 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL20227 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL20528 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL33179 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL30475 | — | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL7130 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL33010 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL268088 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL30594 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL418741 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL33750 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL6771 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL417461 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL266025 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL20466 | — | Ki | = | 70.79 | nM | 7.15 |
| CHEMBL20480 | — | Ki | = | 72.44 | nM | 7.14 |
| CHEMBL441503 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL284133 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL286618 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL34043 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL280726 | — | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL34217 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL30884 | — | Ki | = | 331.13 | nM | 6.48 |
| CHEMBL33739 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL266319 | — | Ki | = | 389.05 | nM | 6.41 |
| CHEMBL285890 | — | Ki | = | 524.81 | nM | 6.28 |
| CHEMBL7435 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL33696 | — | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL34680 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL21051 | — | Ki | = | 1862.09 | nM | 5.73 |
| CHEMBL34270 | — | Ki | = | 2187.76 | nM | 5.66 |
| CHEMBL268356 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL20911 | — | Ki | = | 8511.38 | nM | 5.07 |
| CHEMBL33469 | — | Ki | = | 162181.01 | nM | - |