Assay Detail
Binding
CHEMBL661960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 7.28 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62345 | — | — | 1 | 8.54 |
| CHEMBL294542 | — | — | 1 | 8.47 |
| CHEMBL156559 | — | — | 1 | 8.43 |
| CHEMBL413768 | — | — | 1 | 8.42 |
| CHEMBL433640 | — | — | 1 | 8.38 |
| CHEMBL278447 | — | — | 1 | 8.35 |
| CHEMBL292298 | — | — | 1 | 8.11 |
| CHEMBL62887 | — | — | 1 | 8.10 |
| CHEMBL3144564 | — | — | 1 | 7.89 |
| CHEMBL292519 | — | — | 1 | 7.85 |
| CHEMBL293026 | — | — | 1 | 7.85 |
| CHEMBL60385 | — | — | 1 | 7.82 |
| CHEMBL3144536 | — | — | 1 | 7.80 |
| CHEMBL294304 | — | — | 1 | 7.72 |
| CHEMBL413548 | — | — | 1 | 7.68 |
| CHEMBL387073 | — | — | 1 | 7.66 |
| CHEMBL3144537 | — | — | 1 | 7.66 |
| CHEMBL292071 | — | — | 1 | 7.55 |
| CHEMBL3144554 | — | — | 1 | 7.52 |
| CHEMBL303994 | — | — | 1 | 7.52 |
| CHEMBL3144551 | — | — | 1 | 7.48 |
| CHEMBL418123 | — | — | 1 | 7.48 |
| CHEMBL3144542 | — | — | 1 | 7.42 |
| CHEMBL292471 | — | — | 1 | 7.41 |
| CHEMBL3144565 | — | — | 1 | 7.41 |
| CHEMBL3144548 | — | — | 1 | 7.40 |
| CHEMBL3144550 | — | — | 1 | 7.31 |
| CHEMBL292490 | — | — | 1 | 7.30 |
| CHEMBL302911 | — | — | 1 | 7.28 |
| CHEMBL3144539 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62345 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL294542 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL156559 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL413768 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL433640 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL278447 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL292298 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL62887 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3144564 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL292519 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL293026 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL60385 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3144536 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL294304 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL413548 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL387073 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3144537 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL292071 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3144554 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL303994 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3144551 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL418123 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3144542 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL292471 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3144565 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3144548 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3144550 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL292490 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL302911 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3144539 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL59404 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3144560 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3144553 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3144563 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3144555 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3144566 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3144538 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL418500 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3144561 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3144567 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3144549 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3144540 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3144562 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3144543 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3144535 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3144552 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3144546 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3144544 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3144531 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL433636 | — | IC50 | = | 310.0 | nM | 6.51 |