Assay Detail
Binding
CHEMBL661965
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Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.00 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428666 | — | — | 1 | 9.51 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.22 |
| CHEMBL262197 | — | — | 1 | 9.12 |
| CHEMBL333477 | — | — | 1 | 8.59 |
| CHEMBL420161 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428666 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL1121 | SINCALIDE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL262197 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL333477 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL420161 | — | Ki | = | 2.66 | nM | 8.57 |