Assay Detail
Binding
CHEMBL661967
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Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.14 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.55 |
| CHEMBL3143501 | — | — | 1 | 6.57 |
| CHEMBL2371222 | — | — | 1 | 5.66 |
| CHEMBL2371224 | — | — | 1 | 5.64 |
| CHEMBL2371221 | — | — | 1 | 5.61 |
| CHEMBL2371225 | — | — | 1 | 5.54 |
| CHEMBL120632 | TETRAGASTRIN | -1.0 | 1 | 4.44 |
| CHEMBL2371223 | — | — | 1 | - |
| CHEMBL333477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL3143501 | — | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL2371222 | — | Ki | = | 2210.0 | nM | 5.66 |
| CHEMBL2371224 | — | Ki | = | 2293.0 | nM | 5.64 |
| CHEMBL2371221 | — | Ki | = | 2472.0 | nM | 5.61 |
| CHEMBL2371225 | — | Ki | = | 2880.0 | nM | 5.54 |
| CHEMBL120632 | TETRAGASTRIN | Ki | = | 36133.0 | nM | 4.44 |
| CHEMBL2371223 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL333477 | — | Ki | > | 5000.0 | nM | - |