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Assay Detail

CHEMBL662058

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Coagulation factor X (CHEMBL3656)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.
Choi-Sledeski YM, Becker MR, Green DM, Davis R, Ewing WR, Mason HJ, Ly C, Spada A, Liang G, Cheney D, Barton J, Chu V, Brown K, Colussi D, Bentley R, Leadley R, Dunwiddie C, Pauls HW.
Bioorg Med Chem Lett (1999) 9 : 2539 -2544
PubMed 10498204 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.06 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332256 1 8.22
CHEMBL85938 1 8.22
CHEMBL331943 1 8.15
CHEMBL316053 1 7.66
CHEMBL85757 1 7.58
CHEMBL327600 1 7.33
CHEMBL86026 1 7.10
CHEMBL315218 1 6.75
CHEMBL83532 1 6.60
CHEMBL419490 1 6.43
CHEMBL314909 1 6.05
CHEMBL86343 1 5.92
CHEMBL1907672 1 5.80
CHEMBL315372 1 -
CHEMBL85096 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332256 Ki = 6.0 nM 8.22
CHEMBL85938 Ki = 6.0 nM 8.22
CHEMBL331943 Ki = 7.0 nM 8.15
CHEMBL316053 Ki = 22.0 nM 7.66
CHEMBL85757 Ki = 26.0 nM 7.58
CHEMBL327600 Ki = 47.0 nM 7.33
CHEMBL86026 Ki = 80.0 nM 7.10
CHEMBL315218 Ki = 180.0 nM 6.75
CHEMBL83532 Ki = 250.0 nM 6.60
CHEMBL419490 Ki = 370.0 nM 6.43
CHEMBL314909 Ki = 890.0 nM 6.05
CHEMBL86343 Ki = 1200.0 nM 5.92
CHEMBL1907672 Ki = 1600.0 nM 5.80
CHEMBL315372 Ki > 1200.0 nM -
CHEMBL85096 Ki > 1200.0 nM -