Assay Detail
Binding
CHEMBL662060
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Inhibitory activity against Coagulation factor X
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of benzamidine-type inhibitors of factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.73 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135041 | — | — | 1 | 6.34 |
| CHEMBL135815 | — | — | 1 | 6.28 |
| CHEMBL336844 | — | — | 1 | 6.24 |
| CHEMBL423699 | — | — | 1 | 6.08 |
| CHEMBL137780 | — | — | 1 | 5.80 |
| CHEMBL135998 | — | — | 1 | 5.75 |
| CHEMBL341933 | — | — | 1 | 5.58 |
| CHEMBL137311 | — | — | 1 | 5.38 |
| CHEMBL135198 | — | — | 1 | 5.32 |
| CHEMBL133027 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135041 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL135815 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL336844 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL423699 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL137780 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL135998 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL341933 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL137311 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL135198 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL133027 | — | Ki | = | 29000.0 | nM | 4.54 |