Assay Detail
Binding
CHEMBL662083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of Chymotrypsinogen
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.72 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102115 | — | — | 1 | 8.15 |
| CHEMBL100672 | — | — | 1 | 7.43 |
| CHEMBL457155 | — | — | 1 | 7.16 |
| CHEMBL323544 | — | — | 1 | 4.15 |
| CHEMBL101030 | — | — | 1 | - |
| CHEMBL102081 | — | — | 1 | - |
| CHEMBL102134 | — | — | 1 | - |
| CHEMBL323543 | — | — | 1 | - |
| CHEMBL100989 | — | — | 1 | - |
| CHEMBL101041 | — | — | 1 | - |
| CHEMBL99622 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102115 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL100672 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL457155 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL323544 | — | IC50 | = | 70300.0 | nM | 4.15 |
| CHEMBL101030 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL102081 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL102134 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL323543 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL100989 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL101041 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL99622 | — | IC50 | > | 100.0 | nM | - |