Assay Detail
Binding
CHEMBL662153
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Evaluated using an SPA assay with recombinant human [125I]IL-8 and membranes prepared from Sf9 cells expressing human CXCR2
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nicotinamide N-oxides as CXCR2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.70 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57680 | — | — | 1 | 7.50 |
| CHEMBL301424 | — | — | 1 | 7.05 |
| CHEMBL294095 | — | — | 1 | 6.89 |
| CHEMBL61835 | — | — | 1 | 6.89 |
| CHEMBL58619 | — | — | 1 | 6.55 |
| CHEMBL61655 | — | — | 1 | 6.40 |
| CHEMBL62108 | — | — | 1 | 6.34 |
| CHEMBL60066 | — | — | 1 | 6.00 |
| CHEMBL293139 | — | — | 1 | - |
| CHEMBL59734 | — | — | 1 | - |
| CHEMBL292767 | — | — | 1 | - |
| CHEMBL291368 | — | — | 1 | - |
| CHEMBL60115 | — | — | 1 | - |
| CHEMBL60578 | — | — | 1 | - |
| CHEMBL58561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57680 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL301424 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL294095 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL61835 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL58619 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL61655 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL62108 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL60066 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL293139 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL59734 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL292767 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL291368 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL60115 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL60578 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL58561 | — | IC50 | > | 20000.0 | nM | - |