Assay Detail
Binding
CHEMBL662228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase catalytic subunit (CHEMBL1872) ↗| Type | SINGLE PROTEIN |
| Organism | Herpes simplex virus (type 1 / strain 17) |
Publication
Synthesis of esters of phosphonoformic acid and their antiherpes activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 4.18 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92173 | PHENYL DIPHENOXYPHOSPHINECARBOXYLATE OXIDE | — | 1 | 4.41 |
| CHEMBL91679 | — | — | 1 | 4.36 |
| CHEMBL273301 | SODIUM PHENYL PHENOXYCARBONYLPHOSPHONATE | — | 1 | 4.28 |
| CHEMBL328911 | — | — | 1 | 4.27 |
| CHEMBL424242 | — | — | 1 | 4.14 |
| CHEMBL754 | FOSCARNET SODIUM | 4.0 | 1 | 4.13 |
| CHEMBL91834 | DISODIUM OXIDO(PHENOXY)PHOSPHINECARBOXYLATE OXIDE | — | 1 | 4.10 |
| CHEMBL90955 | — | — | 1 | 4.06 |
| CHEMBL90954 | — | — | 1 | 4.05 |
| CHEMBL91431 | — | — | 1 | 4.01 |
| CHEMBL91569 | — | — | 1 | - |
| CHEMBL314377 | — | — | 1 | - |
| CHEMBL88552 | — | — | 1 | - |
| CHEMBL90982 | DISODIUM BUTOXYCARBONYLPHOSPHONATE | — | 1 | - |
| CHEMBL414219 | SODIUM METHYL PHENOXYCARBONYLPHOSPHONATE | — | 1 | - |
| CHEMBL92550 | — | — | 1 | - |
| CHEMBL261980 | DISODIUM ISOPROPOXYCARBONYLPHOSPHONATE | — | 1 | - |
| CHEMBL90095 | SODIUM BUTYL METHOXYCARBONYLPHOSPHONATE | — | 1 | - |
| CHEMBL91591 | BENZYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | — | 1 | - |
| CHEMBL90381 | — | — | 1 | - |
| CHEMBL90437 | METHYL DIBUTOXYPHOSPHINECARBOXYLATE OXIDE | — | 1 | - |
| CHEMBL92372 | — | — | 1 | - |
| CHEMBL314735 | — | — | 1 | - |
| CHEMBL327318 | — | — | 1 | - |
| CHEMBL90949 | BUTYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | — | 1 | - |
| CHEMBL327238 | — | — | 1 | - |
| CHEMBL91262 | CYCLOHEXYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | — | 1 | - |
| CHEMBL91958 | — | — | 1 | - |
| CHEMBL92306 | DISODIUM ETHOXYCARBONYLPHOSPHONATE | — | 1 | - |
| CHEMBL89984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92173 | PHENYL DIPHENOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL91679 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL273301 | SODIUM PHENYL PHENOXYCARBONYLPHOSPHONATE | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL328911 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL424242 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL754 | FOSCARNET SODIUM | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL91834 | DISODIUM OXIDO(PHENOXY)PHOSPHINECARBOXYLATE OXIDE | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL90955 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL90954 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL91431 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL90534 | SODIUM ETHYL ETHOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL90200 | DISODIUM (BENZYLOXY)CARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91500 | METHYL DIISOPROPOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91401 | — | IC50 | = | 165000.0 | nM | - |
| CHEMBL91487 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL329654 | SODIUM METHYL (BENZYLOXY)CARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL314538 | DISODIUM (CYCLOHEXYLOXY)CARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91590 | ISOPROPYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91174 | DISODIUM PHENOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL315606 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL91546 | PHENYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL90964 | DISODIUM METHOXY(OXIDO)PHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL89434 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL90135 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL329550 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL330012 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL91883 | DISODIUM ETHOXY(OXIDO)PHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL89780 | SODIUM PHENYL ETHOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91564 | DISODIUM (CYCLOPENTYLMETHOXY)CARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91202 | CYCLOPENTYLMETHYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL90437 | METHYL DIBUTOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL89984 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL92306 | DISODIUM ETHOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91958 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL91262 | CYCLOHEXYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL327238 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL90949 | BUTYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL327318 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL314735 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL92372 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL90381 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL91569 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL314377 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL88552 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL90982 | DISODIUM BUTOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL414219 | SODIUM METHYL PHENOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL92550 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL261980 | DISODIUM ISOPROPOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL90095 | SODIUM BUTYL METHOXYCARBONYLPHOSPHONATE | IC50 | > | 500000.0 | nM | - |
| CHEMBL91591 | BENZYL DIMETHOXYPHOSPHINECARBOXYLATE OXIDE | IC50 | > | 500000.0 | nM | - |