Assay Detail
Binding
CHEMBL662240
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The inhibitory concentration of compound against Dihydrofolate reductases on Toxoplasma gondii
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.05 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142176 | — | — | 1 | 5.51 |
| CHEMBL400485 | — | — | 1 | 4.93 |
| CHEMBL140323 | — | — | 1 | 4.70 |
| CHEMBL400364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142176 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL400485 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL140323 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL400364 | — | IC50 | = | 244000.0 | nM | - |