Assay Detail
Binding
CHEMBL662244
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Apparent binding affinity for human placental Cytochrome P450 19A1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.59 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99204 | — | — | 1 | 7.88 |
| CHEMBL3349657 | — | — | 1 | 7.78 |
| CHEMBL3245357 | — | — | 1 | 7.75 |
| CHEMBL98463 | — | — | 1 | 7.72 |
| CHEMBL3349659 | — | — | 1 | 7.44 |
| CHEMBL3349655 | — | — | 1 | 7.40 |
| CHEMBL3349658 | — | — | 1 | 7.40 |
| CHEMBL3349656 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99204 | — | Ki | = | 13.1 | nM | 7.88 |
| CHEMBL3349657 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL3245357 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL98463 | — | Ki | = | 18.9 | nM | 7.72 |
| CHEMBL3349659 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3349655 | — | Ki | = | 40.2 | nM | 7.40 |
| CHEMBL3349658 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL3349656 | — | Ki | = | 44.5 | nM | 7.35 |