Assay Detail
Binding
CHEMBL662245
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The binding affinity was determined on Cytochrome P450 19A1 by analysis of Dixon plot
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.77 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1629804 | — | — | 1 | 7.89 |
| CHEMBL71152 | — | — | 1 | 7.24 |
| CHEMBL2311169 | — | — | 1 | 6.92 |
| CHEMBL262723 | — | — | 1 | 6.66 |
| CHEMBL70367 | — | — | 1 | 6.60 |
| CHEMBL1630911 | — | — | 1 | 6.00 |
| CHEMBL302305 | — | — | 1 | 5.75 |
| CHEMBL71117 | — | — | 1 | 5.70 |
| CHEMBL71082 | — | — | 1 | 5.62 |
| CHEMBL71612 | — | — | 1 | 5.52 |
| CHEMBL68674 | — | — | 1 | 5.52 |
| CHEMBL311400 | — | — | 1 | 5.28 |
| CHEMBL302249 | — | — | 1 | 5.26 |
| CHEMBL71363 | — | — | 1 | 4.96 |
| CHEMBL302741 | — | — | 1 | 4.96 |
| CHEMBL71169 | — | — | 1 | 4.89 |
| CHEMBL302530 | — | — | 1 | 4.82 |
| CHEMBL421491 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1629804 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL71152 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL2311169 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL262723 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL70367 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1630911 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL302305 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL71117 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL71082 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL71612 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL68674 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL311400 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL302249 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL71363 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL302741 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL71169 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL302530 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL421491 | — | Ki | = | 45000.0 | nM | 4.35 |