Assay Detail
Binding
CHEMBL662248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental cytochrome P450 19A1 with androstenedione
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.96 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38472 | — | — | 1 | 6.70 |
| CHEMBL39661 | — | — | 1 | 6.32 |
| CHEMBL289116 | ROGLETIMIDE | 2.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38472 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL39661 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL289116 | ROGLETIMIDE | Ki | = | 14000.0 | nM | 4.85 |