Assay Detail
Binding
CHEMBL662250
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Time dependent inactivation of Cytochrome P450 19A1 was obtained by Kitz-Wilson plot
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.76 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70367 | — | — | 1 | 6.82 |
| CHEMBL262723 | — | — | 1 | 6.75 |
| CHEMBL71082 | — | — | 1 | 5.58 |
| CHEMBL302741 | — | — | 1 | 4.96 |
| CHEMBL71169 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70367 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL262723 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL71082 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL302741 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL71169 | — | Ki | = | 20000.0 | nM | 4.70 |