Assay Detail
Binding
CHEMBL662287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.86 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 9.64 |
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.55 |
| CHEMBL264273 | — | — | 1 | 9.25 |
| CHEMBL437661 | — | — | 1 | 8.33 |
| CHEMBL2370588 | — | — | 1 | 8.19 |
| CHEMBL267329 | — | — | 1 | 8.04 |
| CHEMBL384731 | — | — | 1 | 7.56 |
| CHEMBL266990 | — | — | 1 | 7.54 |
| CHEMBL273880 | — | — | 1 | 7.33 |
| CHEMBL216831 | — | — | 1 | 7.27 |
| CHEMBL384618 | — | — | 1 | 6.52 |
| CHEMBL440259 | — | — | 1 | 6.50 |
| CHEMBL386304 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1121 | SINCALIDE | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL264273 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL437661 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL2370588 | — | Ki | = | 6.43 | nM | 8.19 |
| CHEMBL267329 | — | Ki | = | 9.11 | nM | 8.04 |
| CHEMBL384731 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL266990 | — | Ki | = | 29.2 | nM | 7.54 |
| CHEMBL273880 | — | Ki | = | 47.3 | nM | 7.33 |
| CHEMBL216831 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL384618 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL440259 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL386304 | — | Ki | = | 334.0 | nM | 6.48 |