Assay Detail
Binding
CHEMBL662433
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In vitro inhibition of human placental Cytochrome P450 19A1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.66 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31760 | — | — | 1 | 9.15 |
| CHEMBL31224 | — | — | 1 | 8.54 |
| CHEMBL31215 | S-FADROZOLE | — | 1 | 8.49 |
| CHEMBL29482 | — | — | 1 | 8.46 |
| CHEMBL31456 | — | — | 1 | 8.11 |
| CHEMBL285809 | — | — | 1 | 6.63 |
| CHEMBL287677 | DEXFADROSTAT | 2.0 | 1 | 6.17 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31760 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL31224 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL31215 | S-FADROZOLE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL29482 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL31456 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL285809 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL287677 | DEXFADROSTAT | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 1900.0 | nM | 5.72 |