Assay Detail
Binding
CHEMBL662467
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Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 5.54 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.00 |
| CHEMBL1328 | PENTAGASTRIN | 4.0 | 1 | 8.17 |
| CHEMBL125925 | — | — | 1 | 6.70 |
| CHEMBL339453 | — | — | 1 | 6.52 |
| CHEMBL124396 | — | — | 1 | 6.52 |
| CHEMBL339041 | — | — | 1 | 6.40 |
| CHEMBL340630 | — | — | 1 | 6.40 |
| CHEMBL125874 | — | — | 1 | 6.40 |
| CHEMBL340463 | — | — | 1 | 6.30 |
| CHEMBL124832 | — | — | 1 | 6.30 |
| CHEMBL340413 | — | — | 1 | 6.22 |
| CHEMBL339134 | — | — | 1 | 6.16 |
| CHEMBL421474 | — | — | 1 | 6.10 |
| CHEMBL123684 | — | — | 1 | 6.10 |
| CHEMBL334171 | — | — | 1 | 6.10 |
| CHEMBL331413 | — | — | 1 | 6.05 |
| CHEMBL124764 | — | — | 1 | 6.00 |
| CHEMBL338134 | — | — | 1 | 5.92 |
| CHEMBL421438 | — | — | 1 | 5.92 |
| CHEMBL124509 | — | — | 1 | 5.80 |
| CHEMBL338929 | — | — | 1 | 5.72 |
| CHEMBL341143 | — | — | 1 | 5.72 |
| CHEMBL124732 | — | — | 1 | 5.64 |
| CHEMBL2111826 | — | — | 1 | 5.64 |
| CHEMBL124780 | — | — | 1 | 5.64 |
| CHEMBL122922 | — | — | 1 | 5.64 |
| CHEMBL124155 | — | — | 1 | 5.57 |
| CHEMBL2111825 | — | — | 1 | 5.55 |
| CHEMBL124378 | — | — | 1 | 5.54 |
| CHEMBL2111827 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1328 | PENTAGASTRIN | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL125925 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL339453 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL124396 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL339041 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL340630 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL125874 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL340463 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL124832 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL340413 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL339134 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL421474 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL334171 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL123684 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL331413 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL124764 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL338134 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL421438 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL124509 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL338929 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL341143 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL122922 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL124780 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL124732 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2111826 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL124155 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2111825 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL124378 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2111827 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL340263 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL24938 | LORGLUMIDE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL125551 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL125703 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL339115 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL123852 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL123720 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2111828 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL124712 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL124805 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL124261 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL124459 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL434250 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL123785 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL123089 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL124822 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL124917 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL435587 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL341505 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL339707 | — | IC50 | = | 16300.0 | nM | 4.79 |