Assay Detail
Binding
CHEMBL662468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.96 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216166 | — | — | 1 | 8.25 |
| CHEMBL2112234 | — | — | 1 | 5.88 |
| CHEMBL2115130 | — | — | 1 | 5.63 |
| CHEMBL2112239 | — | — | 1 | 5.63 |
| CHEMBL116127 | — | — | 1 | 5.21 |
| CHEMBL2112233 | — | — | 1 | 5.14 |
| CHEMBL71229 | — | — | 1 | - |
| CHEMBL2114083 | — | — | 1 | - |
| CHEMBL2114079 | — | — | 1 | - |
| CHEMBL2111545 | — | — | 1 | - |
| CHEMBL2114082 | — | — | 1 | - |
| CHEMBL2112235 | — | — | 1 | - |
| CHEMBL265322 | — | — | 1 | - |
| CHEMBL113718 | IQM-95333 | — | 1 | - |
| CHEMBL366344 | — | — | 1 | - |
| CHEMBL189634 | — | — | 1 | - |
| CHEMBL3350282 | — | — | 1 | - |
| CHEMBL2115131 | — | — | 1 | - |
| CHEMBL2112238 | — | — | 1 | - |
| CHEMBL2114081 | — | — | 1 | - |
| CHEMBL2111548 | — | — | 1 | - |
| CHEMBL2112231 | — | — | 1 | - |
| CHEMBL2115132 | — | — | 1 | - |
| CHEMBL2111551 | — | — | 1 | - |
| CHEMBL2112230 | — | — | 1 | - |
| CHEMBL70575 | — | — | 1 | - |
| CHEMBL2115133 | — | — | 1 | - |
| CHEMBL2111549 | — | — | 1 | - |
| CHEMBL71996 | — | — | 1 | - |
| CHEMBL2111552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216166 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL2112234 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2115130 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL2112239 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL116127 | — | IC50 | = | 6153.0 | nM | 5.21 |
| CHEMBL2112233 | — | IC50 | = | 7159.0 | nM | 5.14 |
| CHEMBL265322 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111550 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL113718 | IQM-95333 | IC50 | > | 10000.0 | nM | - |
| CHEMBL366344 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL189634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350282 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2115131 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2114083 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3350281 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL308115 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112236 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112237 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112232 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2114084 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112231 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111552 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71996 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2115133 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL70575 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112230 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111551 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2115132 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112235 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2114081 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2112238 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL71229 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2114079 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2111545 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2114082 | — | IC50 | > | 10000.0 | nM | - |