Assay Detail
Binding
CHEMBL662470
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Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.70 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14153 | PD-170292 | — | 1 | 8.17 |
| CHEMBL13577 | — | — | 1 | 6.70 |
| CHEMBL13517 | — | — | 1 | 5.24 |
| CHEMBL276613 | — | — | 1 | - |
| CHEMBL276837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14153 | PD-170292 | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL13577 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL13517 | — | IC50 | = | 5799.0 | nM | 5.24 |
| CHEMBL276613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL276837 | — | IC50 | > | 10000.0 | nM | - |