Assay Detail
Binding
CHEMBL662471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.74 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13577 | — | — | 1 | 6.70 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.16 |
| CHEMBL419237 | — | — | 1 | 5.57 |
| CHEMBL125897 | — | — | 1 | 5.43 |
| CHEMBL435407 | — | — | 1 | 5.31 |
| CHEMBL338186 | — | — | 1 | 5.25 |
| CHEMBL331532 | — | — | 1 | - |
| CHEMBL276837 | — | — | 1 | - |
| CHEMBL338146 | — | — | 1 | - |
| CHEMBL421461 | — | — | 1 | - |
| CHEMBL338656 | — | — | 1 | - |
| CHEMBL337988 | — | — | 1 | - |
| CHEMBL124798 | — | — | 1 | - |
| CHEMBL262463 | — | — | 1 | - |
| CHEMBL126160 | — | — | 1 | - |
| CHEMBL273543 | — | — | 1 | - |
| CHEMBL124491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13577 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL419237 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL125897 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL435407 | — | IC50 | = | 4914.0 | nM | 5.31 |
| CHEMBL338186 | — | IC50 | = | 5633.0 | nM | 5.25 |
| CHEMBL331532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL276837 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338146 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL421461 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338656 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL337988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL124798 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL262463 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL126160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL273543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL124491 | — | IC50 | > | 10000.0 | nM | - |