Assay Detail
Binding
CHEMBL662476
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In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
On the significance of the C-terminal primary amide in cholecystokinin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.35 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384035 | — | — | 1 | 8.64 |
| CHEMBL384505 | — | — | 2 | 7.32 |
| CHEMBL216527 | — | — | 1 | 6.30 |
| CHEMBL265147 | — | — | 1 | 6.16 |
| CHEMBL413186 | — | — | 1 | 5.96 |
| CHEMBL268337 | — | — | 1 | 5.66 |
| CHEMBL436690 | — | — | 1 | 5.21 |
| CHEMBL414523 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384035 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL384505 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL384505 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL216527 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL265147 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL413186 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL268337 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL436690 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL414523 | — | IC50 | = | 12000.0 | nM | 4.92 |