Assay Detail
Binding
CHEMBL662479
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Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL3508) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.20 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 9.15 |
| CHEMBL428666 | — | — | 1 | 7.02 |
| CHEMBL420161 | — | — | 1 | 5.44 |
| CHEMBL333477 | — | — | 1 | - |
| CHEMBL262197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL428666 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL420161 | — | Ki | = | 3640.0 | nM | 5.44 |
| CHEMBL333477 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL262197 | — | Ki | > | 3000.0 | nM | - |