Assay Detail
Binding
CHEMBL662559
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Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent, selective, water-soluble benzodiazepine-based CCKB receptor antagonists that contain lipophilic carboxylate surrogates
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 9.33 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75490 | — | — | 1 | 9.62 |
| CHEMBL305649 | — | — | 1 | 9.57 |
| CHEMBL58699 | — | — | 1 | 9.55 |
| CHEMBL75536 | — | — | 1 | 9.52 |
| CHEMBL441989 | — | — | 1 | 9.44 |
| CHEMBL75892 | — | — | 1 | 9.24 |
| CHEMBL306944 | — | — | 1 | 9.23 |
| CHEMBL311154 | — | — | 1 | 9.14 |
| CHEMBL75019 | — | — | 1 | 9.11 |
| CHEMBL306803 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75490 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL305649 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL58699 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL75536 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL441989 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL75892 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL306944 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL311154 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL75019 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL306803 | — | IC50 | = | 1.4 | nM | 8.85 |