Assay Detail
Binding
CHEMBL662560
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Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-a receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319814 | — | — | 1 | 5.96 |
| CHEMBL262767 | — | — | 1 | 5.92 |
| CHEMBL3142899 | — | — | 1 | 5.89 |
| CHEMBL3142905 | — | — | 1 | 5.85 |
| CHEMBL98468 | — | — | 1 | 5.72 |
| CHEMBL3142698 | — | — | 1 | 5.70 |
| CHEMBL3142690 | — | — | 1 | 5.58 |
| CHEMBL3142691 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319814 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL262767 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3142899 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3142905 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL98468 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3142698 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3142690 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3142691 | — | IC50 | = | 3000.0 | nM | 5.52 |