Assay Detail
Binding
CHEMBL662562
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Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Toward developing peptidomimetics: Successful replacement of backbone amide bonds in tetrapeptide-based CCK-A receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.04 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | 4.0 | 1 | 8.80 |
| CHEMBL64605 | — | — | 1 | 7.60 |
| CHEMBL169126 | — | — | 1 | 6.15 |
| CHEMBL171593 | — | — | 1 | 6.14 |
| CHEMBL355836 | — | — | 1 | 5.85 |
| CHEMBL422919 | — | — | 1 | 5.62 |
| CHEMBL436053 | — | — | 1 | 5.60 |
| CHEMBL435465 | — | — | 1 | 5.44 |
| CHEMBL354512 | — | — | 1 | 5.42 |
| CHEMBL171227 | — | — | 1 | 5.35 |
| CHEMBL354171 | — | — | 1 | 5.30 |
| CHEMBL263525 | — | — | 1 | 5.16 |
| CHEMBL354670 | — | — | 1 | - |
| CHEMBL169567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1121 | SINCALIDE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL64605 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL169126 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL171593 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL355836 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL422919 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL436053 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL435465 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL354512 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL171227 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL354171 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL263525 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL354670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL169567 | — | IC50 | > | 10000.0 | nM | - |