Assay Detail
Binding
CHEMBL662564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Relationship between dihedral angles of N1 and C9 substituents in 1,4-benzodiazepines and dual cholecystokinin-A and -B antagonistic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.44 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432266 | — | — | 1 | 10.06 |
| CHEMBL285921 | — | — | 1 | 9.17 |
| CHEMBL285850 | — | — | 1 | 9.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432266 | — | IC50 | = | 0.087 | nM | 10.06 |
| CHEMBL285921 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL285850 | — | IC50 | = | 0.81 | nM | 9.09 |