Assay Detail
Binding
CHEMBL662568
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Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.53 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412238 | — | — | 1 | 9.62 |
| CHEMBL316949 | — | — | 1 | 9.30 |
| CHEMBL316944 | — | — | 1 | 9.23 |
| CHEMBL2310858 | — | — | 1 | 9.05 |
| CHEMBL98631 | — | — | 1 | 8.96 |
| CHEMBL439591 | — | — | 1 | 8.85 |
| CHEMBL2310856 | — | — | 1 | 8.51 |
| CHEMBL318010 | — | — | 1 | 8.47 |
| CHEMBL98332 | — | — | 1 | 8.11 |
| CHEMBL98720 | — | — | 1 | 7.82 |
| CHEMBL316709 | — | — | 1 | 7.80 |
| CHEMBL414793 | — | — | 1 | 7.62 |
| CHEMBL408286 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412238 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL316949 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL316944 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL2310858 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL98631 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL439591 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2310856 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL318010 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL98332 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL98720 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL316709 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL414793 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL408286 | — | IC50 | = | 32.0 | nM | 7.50 |