Assay Detail
Binding
CHEMBL662570
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.01 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143186 | — | — | 1 | 8.72 |
| CHEMBL64605 | — | — | 1 | 7.60 |
| CHEMBL169054 | — | — | 1 | 7.19 |
| CHEMBL2370879 | — | — | 1 | 6.12 |
| CHEMBL333299 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143186 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL64605 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL169054 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2370879 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL333299 | — | IC50 | = | 3840.0 | nM | 5.42 |