Assay Detail
Binding
CHEMBL662657
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In vitro inhibition of human liver cathepsin D.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.84 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112598 | — | — | 1 | 8.31 |
| CHEMBL113208 | — | — | 1 | 7.68 |
| CHEMBL112935 | — | — | 1 | 7.46 |
| CHEMBL325768 | — | — | 1 | 7.39 |
| CHEMBL324009 | — | — | 1 | 7.39 |
| CHEMBL112261 | — | — | 1 | 7.28 |
| CHEMBL33989 | — | — | 1 | 7.20 |
| CHEMBL115214 | — | — | 1 | 7.00 |
| CHEMBL325240 | — | — | 1 | 6.85 |
| CHEMBL443541 | — | — | 1 | 6.66 |
| CHEMBL115297 | — | — | 1 | 6.58 |
| CHEMBL116267 | — | — | 1 | 6.49 |
| CHEMBL114634 | — | — | 1 | 6.34 |
| CHEMBL114278 | — | — | 1 | 6.33 |
| CHEMBL112468 | — | — | 1 | 6.23 |
| CHEMBL116282 | — | — | 1 | 6.21 |
| CHEMBL115660 | — | — | 1 | 6.01 |
| CHEMBL112212 | — | — | 1 | 5.74 |
| CHEMBL322979 | — | — | 1 | - |
| CHEMBL324737 | — | — | 1 | - |
| CHEMBL111720 | — | — | 1 | - |
| CHEMBL113876 | — | — | 1 | - |
| CHEMBL113331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112598 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL113208 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL112935 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL325768 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL324009 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL112261 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL33989 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL115214 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL325240 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL443541 | — | Ki | = | 217.0 | nM | 6.66 |
| CHEMBL115297 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL116267 | — | Ki | = | 322.0 | nM | 6.49 |
| CHEMBL114634 | — | Ki | = | 459.0 | nM | 6.34 |
| CHEMBL114278 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL112468 | — | Ki | = | 586.0 | nM | 6.23 |
| CHEMBL116282 | — | Ki | = | 623.0 | nM | 6.21 |
| CHEMBL115660 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL112212 | — | Ki | = | 1807.0 | nM | 5.74 |
| CHEMBL322979 | — | Ki | > | 5900.0 | nM | - |
| CHEMBL324737 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL111720 | — | Ki | > | 5900.0 | nM | - |
| CHEMBL113876 | — | Ki | > | 5900.0 | nM | - |
| CHEMBL113331 | — | Ki | > | 4000.0 | nM | - |