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Assay Detail

CHEMBL662663

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human cathepsin D
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cathepsin D (CHEMBL2581)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.
Ersmark K, Feierberg I, Bjelic S, Hamelink E, Hackett F, Blackman MJ, Hultén J, Samuelsson B, Aqvist J, Hallberg A.
J Med Chem (2004) 47 : 110 -122
PubMed 14695825 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.23 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL113208 1 7.68
CHEMBL176845 1 7.52
CHEMBL33989 1 7.20
CHEMBL115048 1 6.50
CHEMBL367192 1 -
CHEMBL369831 1 -
CHEMBL367384 1 -
CHEMBL177718 1 -
CHEMBL366394 1 -
CHEMBL367607 1 -
CHEMBL368479 1 -
CHEMBL366393 1 -
CHEMBL367562 1 -
CHEMBL367044 1 -
CHEMBL177374 1 -
CHEMBL426945 1 -
CHEMBL435740 1 -
CHEMBL176888 1 -
CHEMBL369171 1 -
CHEMBL369870 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL113208 Ki = 21.0 nM 7.68
CHEMBL176845 Ki = 30.0 nM 7.52
CHEMBL33989 Ki = 63.0 nM 7.20
CHEMBL115048 Ki = 320.0 nM 6.50
CHEMBL367192 Ki > 2000.0 nM -
CHEMBL369831 Ki > 2000.0 nM -
CHEMBL367384 Ki > 2000.0 nM -
CHEMBL177718 Ki > 2000.0 nM -
CHEMBL366394 Ki > 2000.0 nM -
CHEMBL367607 Ki > 2000.0 nM -
CHEMBL368479 Ki > 2000.0 nM -
CHEMBL366393 Ki > 2000.0 nM -
CHEMBL367562 Ki > 2000.0 nM -
CHEMBL367044 Ki > 2000.0 nM -
CHEMBL177374 Ki > 2000.0 nM -
CHEMBL426945 Ki > 2000.0 nM -
CHEMBL435740 Ki > 2000.0 nM -
CHEMBL176888 Ki > 2000.0 nM -
CHEMBL369171 Ki > 2000.0 nM -
CHEMBL369870 Ki > 2000.0 nM -