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Assay Detail

CHEMBL662976

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of choline acetyltransferase isolated from squid head ganglia
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism squid
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Choline O-acetyltransferase (CHEMBL4039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Interaction of aromatic dyes with the coenzyme A binding site of choline acetyltransferase.
Mautner HG, Merrill RE, Currier SF, Harvey G.
J Med Chem (1981) 24 : 1534 -1537
PubMed 7310833 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.69 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL429694 CONGO RED -1.0 1 7.00
CHEMBL1160025 1 6.10
CHEMBL1160031 REACTIVE BLUE 2 1 6.10
CHEMBL1160032 1 5.92
CHEMBL1160026 1 5.75
CHEMBL3144208 1 5.64
CHEMBL398231 1 5.52
CHEMBL1332616 ERYTHROSINE 1 5.10
CHEMBL1213327 COENZYME_A 3.0 1 4.12
CHEMBL1160036 1 -
CHEMBL285527 1 -
CHEMBL1160030 1 -
CHEMBL1160024 1 -
CHEMBL1160029 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL429694 CONGO RED Ki = 100.0 nM 7.00
CHEMBL1160025 Ki = 800.0 nM 6.10
CHEMBL1160031 REACTIVE BLUE 2 Ki = 800.0 nM 6.10
CHEMBL1160032 Ki = 1200.0 nM 5.92
CHEMBL1160026 Ki = 1800.0 nM 5.75
CHEMBL3144208 Ki = 2300.0 nM 5.64
CHEMBL398231 Ki = 3000.0 nM 5.52
CHEMBL1332616 ERYTHROSINE Ki = 8000.0 nM 5.10
CHEMBL1213327 COENZYME_A Ki = 75000.0 nM 4.12
CHEMBL1160036 Ki = 150000.0 nM -
CHEMBL285527 Ki = 200000.0 nM -
CHEMBL1160030 Ki = 800000.0 nM -
CHEMBL1160024 Ki = 1500000.0 nM -
CHEMBL1160029 Ki = 1600000.0 nM -