Assay Detail
Binding
CHEMBL663078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.88 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.21 |
| CHEMBL149238 | — | — | 1 | 4.90 |
| CHEMBL151212 | — | — | 1 | 4.87 |
| CHEMBL151691 | — | — | 1 | 4.80 |
| CHEMBL357775 | — | — | 1 | 4.78 |
| CHEMBL148903 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL149238 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL151212 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL151691 | — | IC50 | = | 15660.0 | nM | 4.80 |
| CHEMBL357775 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL148903 | — | IC50 | = | 20000.0 | nM | 4.70 |