Assay Detail
Binding
CHEMBL663079
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Inhibition of Cytochrome P450 19A1 in human placenta
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.30 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88412 | — | — | 1 | 6.48 |
| CHEMBL88918 | — | — | 1 | 6.10 |
| CHEMBL39661 | — | — | 1 | 6.10 |
| CHEMBL314125 | — | — | 1 | 5.82 |
| CHEMBL91363 | — | — | 1 | 5.62 |
| CHEMBL89102 | — | — | 1 | 5.60 |
| CHEMBL88421 | — | — | 1 | 5.52 |
| CHEMBL313485 | — | — | 1 | 5.50 |
| CHEMBL441404 | — | — | 1 | 5.44 |
| CHEMBL88842 | — | — | 1 | 5.40 |
| CHEMBL289116 | ROGLETIMIDE | 2.0 | 1 | 5.30 |
| CHEMBL444844 | — | — | 1 | 5.22 |
| CHEMBL316262 | — | — | 1 | 5.18 |
| CHEMBL330452 | — | — | 1 | 5.00 |
| CHEMBL90856 | — | — | 1 | 5.00 |
| CHEMBL312960 | — | — | 1 | 4.68 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 4.52 |
| CHEMBL314991 | — | — | 1 | 4.52 |
| CHEMBL314351 | — | — | 1 | 4.51 |
| CHEMBL328546 | — | — | 1 | 4.40 |
| CHEMBL327239 | — | — | 1 | - |
| CHEMBL89046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88412 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL88918 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL39661 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL314125 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL91363 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL89102 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL88421 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL313485 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL441404 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL88842 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL289116 | ROGLETIMIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL444844 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL316262 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL330452 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL90856 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL312960 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL314991 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL314351 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL328546 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL327239 | — | IC50 | = | 385000.0 | nM | - |
| CHEMBL89046 | — | IC50 | = | 245000.0 | nM | - |