Assay Detail
Binding
CHEMBL663085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.03 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 8.43 |
| CHEMBL127969 | — | — | 1 | 4.89 |
| CHEMBL124015 | — | — | 1 | 4.77 |
| CHEMBL169703 | TIFLUADOM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9506 | DEVAZEPIDE | Ki | = | 3.69 | nM | 8.43 |
| CHEMBL127969 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL124015 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL169703 | TIFLUADOM | Ki | > | 100000.0 | nM | - |