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Assay Detail

CHEMBL663104

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
inhibitory activity against alpha chymotrypsin from bovine pancreas.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Chymotrypsin-C (CHEMBL2386)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.
Akahoshi F, Ashimori A, Sakashita H, Yoshimura T, Imada T, Nakajima M, Mitsutomi N, Kuwahara S, Ohtsuka T, Fukaya C, Miyazaki M, Nakamura N.
J Med Chem (2001) 44 : 1286 -1296
PubMed 11312927 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.03 8.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL247767 CHYMOSTATIN 1 8.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL247767 CHYMOSTATIN Ki = 9.36 nM 8.03