Assay Detail
Binding
CHEMBL663135
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Concentration required for 50% inhibition against dihydrofolate reductase of Streptococcus faecium
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterococcus faecium |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.26 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.92 |
| CHEMBL422395 | — | — | 1 | 6.52 |
| CHEMBL34918 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL422395 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL34918 | — | IC50 | = | 460.0 | nM | 6.34 |