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Assay Detail

CHEMBL663144

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Functional
Effective dose was measured by the stimulation of mitogenesis at dopamine D4.2 receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(4) dopamine receptor (CHEMBL219)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.
Hübner H, Kraxner J, Gmeiner P.
J Med Chem (2000) 43 : 4563 -4569
PubMed 11087581 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 8.03 8.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL143761 1 8.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL143761 EC50 = 9.4 nM 8.03