Assay Detail
Functional
CHEMBL663147
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Cytotoxic Activity was evaluated against D54 tumor cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | D54 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.50 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170758 | — | — | 1 | 8.34 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.80 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.22 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170758 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 230.0 | nM | 6.64 |