Assay Detail
Binding
CHEMBL663244
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In vitro inhibition of cytochrome P450 19A1
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203762 | — | — | 1 | 8.70 |
| CHEMBL9298 | FADROZOLE | 2.0 | 2 | 8.34 |
| CHEMBL468419 | FADROZOLE HYDROCHLORIDE | -1.0 | 1 | 8.19 |
| CHEMBL1203766 | — | — | 1 | 8.12 |
| CHEMBL162834 | — | — | 1 | 7.85 |
| CHEMBL348913 | — | — | 1 | 7.84 |
| CHEMBL349822 | — | — | 1 | 7.82 |
| CHEMBL162496 | — | — | 1 | 7.82 |
| CHEMBL1203757 | — | — | 1 | 7.75 |
| CHEMBL1203760 | — | — | 1 | 7.68 |
| CHEMBL163420 | — | — | 1 | 7.03 |
| CHEMBL163413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203762 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL468419 | FADROZOLE HYDROCHLORIDE | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL1203766 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL162834 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL348913 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL349822 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL162496 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1203757 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL1203760 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL9298 | FADROZOLE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL163420 | — | IC50 | = | 92.9 | nM | 7.03 |
| CHEMBL163413 | — | IC50 | > | 1000.0 | nM | - |