Assay Detail
Binding
CHEMBL663246
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Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylase
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereoisomers of ketoconazole: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.12 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 6.71 |
| CHEMBL319160 | — | — | 1 | 6.26 |
| CHEMBL328863 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL319160 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL328863 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 2400.0 | nM | 5.62 |