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Assay Detail

CHEMBL663392

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory activity against Cholecystokinin type A receptor using [125I]BH-CCK-8S as radioligand in guinea pig pancreatic cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Cholecystokinin receptor type A (CHEMBL3501)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons.
Kalindjian SB, Buck IM, Davies JM, Dunstone DJ, Hudson ML, Low CM, McDonald IM, Pether MJ, Steel KI, Tozer MJ, Vinter JG.
J Med Chem (1996) 39 : 1806 -1815
PubMed 8627604 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 5.54 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301810 1 6.07
CHEMBL53237 1 6.05
CHEMBL299387 1 6.04
CHEMBL299540 1 5.89
CHEMBL24313 1 5.83
CHEMBL296167 1 5.68
CHEMBL298521 1 5.65
CHEMBL298551 1 5.59
CHEMBL300456 1 5.55
CHEMBL298861 1 5.50
CHEMBL415936 1 5.48
CHEMBL280248 1 5.47
CHEMBL53129 1 5.45
CHEMBL14557 1 5.44
CHEMBL297480 1 5.42
CHEMBL301777 1 5.13
CHEMBL301740 1 5.09
CHEMBL301095 1 5.08
CHEMBL52740 1 4.93

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301810 Ki = 851.14 nM 6.07
CHEMBL53237 Ki = 891.25 nM 6.05
CHEMBL299387 Ki = 912.01 nM 6.04
CHEMBL299540 Ki = 1288.25 nM 5.89
CHEMBL24313 Ki = 1479.11 nM 5.83
CHEMBL296167 Ki = 2089.3 nM 5.68
CHEMBL298521 Ki = 2238.72 nM 5.65
CHEMBL298551 Ki = 2570.4 nM 5.59
CHEMBL300456 Ki = 2818.38 nM 5.55
CHEMBL298861 Ki = 3162.28 nM 5.50
CHEMBL415936 Ki = 3311.31 nM 5.48
CHEMBL280248 Ki = 3388.44 nM 5.47
CHEMBL53129 Ki = 3548.13 nM 5.45
CHEMBL14557 Ki = 3630.78 nM 5.44
CHEMBL297480 Ki = 3801.89 nM 5.42
CHEMBL301777 Ki = 7413.1 nM 5.13
CHEMBL301740 Ki = 8128.31 nM 5.09
CHEMBL301095 Ki = 8317.64 nM 5.08
CHEMBL52740 Ki = 11748.98 nM 4.93