Assay Detail
Binding
CHEMBL663447
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Compound was evaluated for its binding affinity against Cannabinoid receptor 1 in Guinea pig ileum (GPI) using [3H]CP-55940 ligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.65 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | — | 1 | 8.61 |
| CHEMBL127644 | — | — | 1 | 8.56 |
| CHEMBL123916 | — | — | 1 | 8.54 |
| CHEMBL148805 | — | — | 1 | 6.83 |
| CHEMBL149599 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | Ki | = | 2.48 | nM | 8.61 |
| CHEMBL127644 | — | Ki | = | 2.72 | nM | 8.56 |
| CHEMBL123916 | — | Ki | = | 2.89 | nM | 8.54 |
| CHEMBL148805 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL149599 | — | Ki | = | 1945.0 | nM | 5.71 |