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Assay Detail

CHEMBL663449

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for its binding affinity against Cannabinoid receptor 1 in Guinea pig ileum (GPI) using [3H]SR-141,716A ligand at site 1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Ileum
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL218)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Reggio PH, Basu-Dutt S, Barnett-Norris J, Castro MT, Hurst DP, Seltzman HH, Roche MJ, Gilliam AF, Thomas BF, Stevenson LA, Pertwee RG, Abood ME.
J Med Chem (1998) 41 : 5177 -5187
PubMed 9857088 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.97 7.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL127644 1 7.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL127644 Ki = 10.8 nM 7.97