Assay Detail
Binding
CHEMBL663595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cyclin-dependent kinase 5-p35nck5a
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.99 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337300 | — | — | 1 | 7.70 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.55 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 6.07 |
| CHEMBL323657 | — | — | 1 | 5.40 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 5.38 |
| CHEMBL134501 | — | — | 1 | 4.92 |
| CHEMBL77217 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337300 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL323657 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL134501 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL77217 | — | IC50 | = | 13000.0 | nM | 4.89 |